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Project: Biomaterials for the assemblage of regenerative-inspired scaffolds for the electrical stimulation of spinal cord

Acronym: BioMaterARISES
Main Objective:
Project BioMaterARISES is an exploratory project that aims at providing new electroconductive materials suitable for tissue engineering. The success of this project will allow to use
the developed materials in the design of novel constructs crucial for potential clinical applications, including reliable in vitro models to study disease progression and study new
therapeutic approaches, and transplantation of autologous cells into patients. The overall goals of the project include:
A. Developing new fully biodegradable/biodispersible and bioactive electrocomposites;
B. Development of the best bioactive cue combination to boost MSC osteogenic differentiation;
C. Development of a bioactive 3D-printing filament, through the incorporation of the best combination of chemical cues (e.g. GAGs, proteins) in the polymer structure.
D. Creation of 3D-constructs suitable for studying the effects of electrical stimulation on bone cells.
Region of Intervention: Portugal, Lisbon; USA, Troy-NY
Reference: EXPL/CTM-CTM/0995/2021
Funding: FCT
Start Date: 01-12-2021
End Date: 31-05-2023
Team: Fábio Filipe Ferreira Garrudo, Jorge Manuel Ferreira Morgado, Deepak Vashishth, Frederico Castelo Ferreira, Marta Monteiro Silva Carvalho, Ana Maria de Matos Charas, Robert John Linhardt, Fuming Zhang, Richard Gross, João Carlos Fernandes da Silva, Carlos A. V. Rodrigues, António Luis Gonçalves de Aguiar
Groups: Organic Electronics – Lx
Partners: SCERG, iBB, IST-Lisbon, Rensselaer Polytechnic Institute, Troy, NY, USA
Local Coordinator: Fábio Filipe Ferreira Garrudo

Associated Publications
  • 8Papers in Journals
  • J. Silva, J. Meneses, F. Garrudo, S. F. Fernandes, N. Alves, F.C.F. Ferreira, P. Pascoal-Faria, Direct coupled electrical stimulation towards improved osteogenic differentiation of human mesenchymal stem/stromal cells: a comparative study of different protocols, Scientific Reports, Vol. 14, No. 1, pp. 1 - 14, March, 2024 | Full text (PDF 3 MBs) | BibTex
  • L. R. Resina, F. Garrudo, C. Aléman, T.S. Esteves, F.C.F. Ferreira, Wireless electrostimulation for cancer treatment: An integrated nanoparticle/coaxial fiber mesh platform, Biomaterials Advances, Vol., No., pp. 213830 - 213830, March, 2024 | BibTex
  • F. Garrudo, A. M. Ferraria Ferraria, AMBR Botelho do Rego, A. Charas, V. André, M. T. Duarte, R. L. Linhardt, F.C.F. Ferreira, J. Morgado, Pseudo-doping effect on structural and electrical properties of polyaniline-camphorsulfonic acid, Synthetic Metals, Vol. 301, No. 117523, pp. 117523 - 117523, January, 2024,
    | Abstract
    | Full text (PDF 8 MBs) | BibTex
  • F. Garrudo, C. F. Faustino, M. E. R. Rosa, M. H. R. Henriques Ribeiro, Exploring Functionalized Magnetic Hydrogel Polyvinyl Alcohol and Chitosan Electrospun Nanofibers, gels, Vol. 9, No. 12, pp. 968 - 968, December, 2023,
    | Abstract
    | Full text (PDF 5 MBs) | BibTex
  • F. B. Barbosa, F. Garrudo, P. A. Alberte, L. R. Resina, M. Carvalho, A. Jain, A. C. Marques, F. Estrany, F. Rawson, C. Aléman, F.C.F. Ferreira, J. C. S. Silva, Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering, Science and Technology of Advanced Materials, Vol. 24, No. 1, pp. 1 - 26, August, 2023,
    | Abstract
    | Full text (PDF 19 MBs) | BibTex
  • F. B. Barbosa, F. Garrudo, A. C. Marques, J. M. S. Cabral, J. Morgado, F.C.F. Ferreira, J. C. S. Silva, Novel Electroactive Mineralized Polyacrylonitrile/PEDOT:PSS Electrospun Nanofibers for Bone Repair Applications, International Journal of Molecular Sciences, Vol. 24, No. 17, pp. 13203 - 13203, August, 2023,
    | Abstract
    | Full text (PDF 3 MBs) | BibTex
  • F. Garrudo, R. L. Linhardt, F.C.F. Ferreira, J. Morgado, Designing Electrical Stimulation Platforms for Neural Cell Cultivation Using Poly(aniline): Camphorsulfonic Acid, Polymers, Vol. 15, No. 12, pp. 2674 - 2674, June, 2023,
    | Abstract
    | Full text (PDF 1 MB) | BibTex
  • F. Garrudo, G. Filippone, L. R. Resina, J. Silva, F. B. Barbosa, L. Ferreira, T.S. Esteves, A. C. Marques, J. Morgado, F.C.F. Ferreira, Production of Blended Poly(acrylonitrile): Poly(ethylenedioxythiophene):Poly(styrene sulfonate) Electrospun Fibers for Neural Applications, Polymers, Vol. 15, No. 13, pp. 2760 - 2760, June, 2023,
    | Abstract
    | Full text (PDF 5 MBs) | BibTex