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Performance assessment of polymer based electrodes for in vitro electrophysiological sensing: the role of the electrode impedance

Medeiros, M. C. R. ; Gomes, H.L. ; al., et.

Performance assessment of polymer based electrodes for in vitro electrophysiological sensing: the role of the electrode impedance, Proc SPIE, San Diego, United States, Vol. 9944, pp. 1 - 8, September, 2016.

Digital Object Identifier: 10.1117/12.2237659

Abstract
Conducting polymer electrodes based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) are used to record extracellular signals from autonomous cardiac contractile cells and glioma cell cultures. The performance of these conducting polymer electrodes is compared with Au electrodes. A small-signal impedance analysis shows that in the presence of an electrolyte, both Au and polymer electrodes establish high capacitive double-layers. However, the polymer/electrolyte interfacial resistance is 3 orders of magnitude lower than the resistance of the metal/electrolyte interface. The polymer low interfacial resistance minimizes the intrinsic thermal noise and increases the system sensitivity. However, when measurements are carried out in current mode a low interfacial resistance partially acts as a short circuit of the interfacial capacitance, this affects the signal shape. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.