A multi-well graphene-multielectrode array device for in vitro 3D electrical stimulation and method to obtain the device
Alves, L.
; Marques, Paula A.A.P. Marques
; Barroca, N. B. B.
; Martins, P. A. A. D. M.
; Figueiredo, B. R. F.
; Silva, R. P. F. F. S.
; Bernardes, A. F. B.
; Abrantes, V. E. M. A.
Instituto de Telecomunicações, Universidade de Aveiro, Graphenest S.A.
Invention Title: A multi-well graphene-multielectrode array device for in vitro 3D electrical stimulation and method to obtain the device
Patent Nr.: US18861386
Type: Patent
Regional Coverage: National
Grant Status: Pending
Priority Date: 29-04-2022
Filing Date: 29-10-2024
Country: United States
External Links:
Abstract
The present disclosure relates to a cell and tissue culture device and method to obtain said device. The cell and tissue culture device comprising: a support electrode comprising: a first electrically non-conductive substrate sheet, a first patterned circuit made of an electrically conductive ink applied on the substrate, a first plurality of patterned graphene dots connected to the first electrically conductive patterned circuit, for applying electrical stimulus to the culture and tissue, a dielectric ink coating having patterned openings for exposing the graphene dots; a multi-well plate comprising a plurality of wells for receiving the culture; a lid electrode comprising: a second electrically non-conductive substrate sheet; a second patterned circuit made of an electrically conductive ink applied on the substrate, a plurality of inserts, each insert for inserting in a well; a second plurality of patterned graphene dots connected to the second electrically conductive patterned circuit, wherein each graphene dot is arranged on an insert for applying electrical stimulus to the culture and tissue, wherein the multi- well plate is arranged between the support electrode and the lid electrode.
